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Sodium-glucose cotransporter 2 (SGLT2) inhibitors have demonstrated both kidney- and heart-protective effects in individuals with CKD, and other agents, such as non-steroidal mineralocorticoid receptor antagonists (ns-MRA), provide cardio-kidney protection in patients with diabetes and kidney disease

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Withdrawal context Russian and Eastern-European trials examined DSIP in opioid- and alcohol-withdrawal settings and reported reduced symptom severity in case-series and open-label work

In older adults, a significant reduction in DBP was noted after six months of consuming a lignan complex (609)

This is important for POTS patients who may be on beta-blockers, midodrine, fludrocortisone, or other medications that interact with fluid management