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For example, the combination of curcumin and resveratrol inhibits NF-B activity by targeting IGF-1R signaling, ultimately leading to apoptosis and cell cycle arrest in natural colon cancer cells, suggesting that IGF-1R may be an anticancer approach (116)

This side effect helped the drug soar in popularity, even though Ozempic hasnt been approved by the FDA for weight loss

doi: 10.1016/j.intimp.2025.114941 Summary Keywords vagus nerve stimulation, Parkinsons disease, microbiota-gut-brain axis, mechanism, intestinal flora Citation Yang L, Fan S, Sun L, Han J, Wang M and Yu T (2025) The role of vagus nerve stimulation in modulating Parkinsons disease via the microbiota-gut-brain axis: a comprehensive review