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Clin Pediatr (Phila) 2006 45(9):864 - 866 H U Rehman

Understanding GLP-1 Receptor Agonists and Their Action GLP-1 (glucagon-like peptide-1) receptor agonists bind directly to GLP-1 receptors located in the intestines, pancreas, and brain

Final research-target dose 2.4 mg + 2.4 mg weekly Titration length ~16 weeks Trial duration 68 weeks (REDEFINE 1 / REDEFINE 2) Route Subcutaneous, once weekly Compound Delivery: 2.4 mg / 2.4 mg Maintenance Pre-blended vials simplify weekly administration to a single injection but lock the ratio at 1:1