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A comprehensive review of recent clinical data highlights that while folate deficiency is common among individuals with ASD, maternal folic acid supplementation does not correlate with higher risk of the disorder, indeed folate therapy has been associated with improved neurodevelopmental outcomes (Vasconcelos et al., 2025)

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Subsequently, CRM1 binds to nucleoporins, specifically Nucleoporin 214/Can protein, directing the complex toward the nuclear pore for transport, while fully spliced HIV-1 mRNAs can exit the nucleus without Rev [38]