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Longitudinal human work is scarce

GHK-Cu: Protects brain cells from oxidative stress, promotes neurogenesis, and enhances cognitive resilience

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Its structurally built into the enzyme superoxide dismutase (SOD), and is essential for the functioning of this enzyme, which is our first line of defense against free radical toxins

When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted