Limitations and Challenges of Nasal Drug Delivery to Brain Despite the potential of the N-to-B drug delivery route to the CNS, there are significant challenges associated with this method of administration
Poor glycemic control further exacerbates these effects, contributing to reduced treatment tolerance, higher infection rates, and shorter survival, particularly in patients with early-stage disease or long-term therapeutic needs
These factors indicate that the GLP-1 RA group is more severely affected by diabetes compared to the DPP-4i group, and the GLP-1 RA group may thus be subject to residual confounding associated with higher fracture risk
(2022) 14:e26735
den Heijer M, Koster T, Blom HJ, Bos GMJ, Brit E, Reitsma PH, Vandenbroucke JP, and Rosendaal FR (1996)