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doi: 10.1371/journal.pntd.0004293 [DOI] [PMC free article] [PubMed] [Google Scholar] 290
Its also important to rotate the injection site after each shot to reduce the risk of skin irritation
Additionally, KYN can be converted into anthranilic acid by kynureninase, which can then undergo nonspecific hydroxylation to form 3-HAA
The 500 Dalton rule suggests small peptides can cross the stratum corneum, but intact copper coordination and hydrophilicity reduce net penetration
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