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Elam M, Lovato L, Ginsberg H

10.1016/j.freeradbiomed.2020.10.012 70 YahyapourR.AminiP.RezapourS.ChekiM.RezaeyanA.FarhoodB.et al (2018)

These findings are probably connected with LPS-mediated activation of TLR4 pathways, which stimulate pro-inflammatory signals and modify insulin receptor substrate 1, altering insulin signaling, inducing inflammation, and insulin resistance

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One cause of such a cytokine storm is an imbalance of the ratio between ACE1 (the pro-inflammatory mediator) and ACE2 (the anti-inflammatory mediator)