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Meta-analyses encompassing more than 170,000 participants have demonstrated a 25% reduction in major adverse cardiovascular events and significant reductions in all-cause mortality

TB-500 and KPV are the thinnest, resting on smaller sets of animal and cell studies for migration/repair and anti-inflammatory activity respectively

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After removing duplicate papers and screening the articles carefully by the title and abstract, thirty-five papers were included

Glutaminase inhibitors, such as CB-839, have shown promise in preclinical studies and early-phase clinical trials, demonstrating their ability to impede glutamine catabolism and disrupt the supply of glutamate, a precursor for numerous biosynthetic pathways critical for cancer cell survival and proliferation [12,55]