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Cobalamin deficiency results in the decrease of this conversion, resulting in high plasma levels of homocysteine, which is associated with a higher risk of cerebrovascular disease, depression, dementia, cellular stress, and apoptosis (64, 70)

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Moreover, although evidence is accumulating that gut microbial is involved in the etiology of obesity (52) and altered by modified IF (4), relevant researches were still rare

Food and Drug Administrations (FDAs) patient-focused drug development initiative