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Of those studies, a few have suggested a positive effect, but the overall evidence is mixed

Continuing Titration: For individuals who, in consultation with their provider, require continued titration and are tolerating the medication well, proceeding to a higher dose is a standard clinical approach

J Inorg Biochem 98: 16341641

And presumably anybody with an IQ above about 60 recognizes that indeed your risk of cardiovascular disease, cancer, Alzheimer's disease in addition to your risk of kidney disease and a whole bunch of other things goes up dramatically as a response to that

In the case of AXO-HSA, IC50 is around 1 mM in Group B and at least 10 fold greater concentration is needed in Group A