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However, modern research indicates that GCGR agonism increases thermogenesis and energy expenditure through the activation of futile cycles in the liver and potentially the recruitment of brown adipose tissue

This asymmetry is strategic: GIPR activation in brown adipose tissue promotes thermogenesis and energy expenditure, while the GLP-1 arm handles satiety and glycemic control

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You should take one dose each week, meaning each pen should last four weeks

These benefits are not simply ascribable to mechanical effects of body weight reduction, as the STEP-HFpEF trial also showed that semaglutide reduced NTproBNP levels compared to placebo, consistent with a direct benefit on hemodynamic congestion 11