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Tell all your healthcare providers that you are taking Saxenda before you are scheduled to have surgery or other procedures Saxenda may cause serious side effects, including: The most common side effects of Saxenda in adults include nausea, diarrhea, constipation, vomiting, injection site reaction, low blood sugar (hypoglycemia), headache, tiredness (fatigue), dizziness, stomach pain, and change in enzyme (lipase) levels in your blood