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That tension, growing demand and political will on one side, limited human trials on the other, is the real story of the next two years

10.1016/j.ijgo.2007.08.018

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Conclusions As discussed above, the role of amino acids in supporting or inhibiting tumor biology and antitumor immune responses can be variable, depending on the tumor type, its mutations, infiltrated immune cells, the presence of other molecules, the biochemical conditions in the TME (oxygen levels, etc), and the metabolism of the cells from the TME, influencing, for example, how they use the amino acids, as a carbon source or as a substrate for enzymes or PTMs