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934 Recent studies have shown increased expression of elabela and APJ in neurons after cerebral I/R injury, with typical morphological and molecular features associated with ferroptosis in neurons, such as mitochondrial shrinkage, iron, and MDA accumulation, upregulation of ACSL4 and ALOX15, and downregulation of GPX4 and xCT

Platinum retained in vascular tissue for up to 30 years causes persistent endothelial damage, elevating long-term vascular disease risk (Herrmann 2020)

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