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Alternatively, PPOs can be activated by fatty acids 17 , acidic pH 18 , detergents, such as sodium dodecyl sulfate (SDS) 19,20 , and proteases 21

Lu, S.C., et al., Insulin and Glucocorticoid Dependence of Hepatic Gamma-Glutamylcysteine Synthetase and Glutathione Synthesis in the Rat Studies in Cultured-Hepatocytes and Invivo

Chen Y, Jiang Z, Zhang C, Zhang L, Chen H, Xiao N, et al

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Oral supplementation works because approximately 1% of an oral dose is absorbed through passive diffusion, bypassing the need for intrinsic factor