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This is why anionic ligands (which tend to be better electron donors) tend to give lower coordination numbers than comparable neutral ligands (which tend to be weaker donors)

But there are other options available for those who want to try a different approach

MTHFR polymorphism and psychiatric diseases Extensive clinical studies demonstrated a significant linkage between MTHFR polymorphism and various diseases, such as cardiovascular diseases, neuronal developmental diseases, cancers as well as psychiatric disorders

For complete comparison, read BPC-157 vs TB-500