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BMI of 30 or above, or BMI of 27 or above with an obesity-related health condition Health conditions such as high blood pressure, insulin resistance, sleep apnea, or elevated cholesterol History of unsuccessful attempts with diet, exercise, or commercial weight loss programs Willingness to combine medication with nutrition, movement, and lifestyle changes Not currently pregnant or planning pregnancy in the near term No contraindications to GLP-1 therapy based on health history and provider review Candidacy for compounded semaglutide and compounded tirzepatide is reviewed individually

GLP-1 receptor activation can influence autonomic signaling, potentially shifting the balance in ways that reduce the neural drive to salivary glands

Clearance = timed urine volume (mL/min) (urine concentration / plasma concentration) Both an accurately timed urine sample and a blood sample must be collected

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[9] This phenomenon occurs because the pharmacological effects that supported weight lossappetite suppression, delayed gastric emptying, and enhanced satietyare no longer present