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Trial populations and endpoints are specific to those studies, and individual outcomes vary

347 Activated TGF- binds to its transmembrane receptor (TR), subsequently inducing the phosphorylation of suppressor of mothers against decapentaplegic (SMAD) and its translocation into the nucleus, which suppresses hepatocyte proliferation by inhibiting the expression of downstream DNA synthesis-related genes

however, they were unsure if the results were applicable to patients with intolerance to metformin, making this a limitation of the study

Monitoring your cycle and discussing any significant changes with your healthcare provider is important

Serious Potential Side Effects Although rare, semaglutide can cause serious side effects