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To further explore the role of the BM microenvironment in promoting mTOR activity in LTR, we analyzed mTOR expression in the non-CAR T cell fraction in the BM, which is composed of non-transduced T cells from the CAR T cell product as well as endogenous reconstituting T cells

Understanding and managing methotrexate nephrotoxicity

A total of 970 potential target genes were obtained from those databases

54 In contrast, when animals were treated with tert-butylhydroperoxide to induce LPO-mediated liver injury, extensive LPOindicated by a 12- to 30-fold increase in these LPO parameterswas necessary to even cause moderate liver injury

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