Glycyrrhizin inhibits the metabolism of diosbulbin B (Yang et al., 2024), promotes bile acid efflux by increasing the expression of Nrf2/Farnesoid X Receptor- Bile Salt Export Pump (FXR-BSEP)/Multidrug Resistance-Associated Protein (MRP)2/P-glycoprotein/UDP-glucuronosyltransferase 1A1(UGT1A1), modulates gut microbiota, alleviates inflammation and oxidative stress, and improves diosbulbin B-induced liver injury (Wang et al., 2025)
Banitalebi Dehkordi M, Madjd Z, Chaleshtori MH, Meshkani R, Nikfarjam L, Kajbafzadeh AM
Lastly, athletes wishing to explore NO enhancers are reminded that a good level of evidence exists for L-citrulline to improve exercise performance, and therefore may consider use of this supplement whilst the intricacies of CM supplementation are discovered (Gonzalez and Trexler 2020)
No orotic acid in urine (that is the key distinction)
doi: 10.1002/jcsm.12833 103 Fernandez-SolaJLluisMSacanellaEEstruchRAntunezEUrbano-MarquezA