[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Miura H., Ozaki N., Sawada M., Isobe K., Ohta T., Nagatsu T
contortus treated with quercetin
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This stimulates the production of excessive testosterone by thecal cells, disrupting the hypothalamic-pituitary-ovarian (HPO) axis, ultimately affecting dominant follicle generation, follicular dysfunction, and ovarian interstitial cell fibrosis ( 2.1.2 Uterus Successful pregnancy, encompassing embryo adhesion, implantation, growth, invasion of trophocytes, and formation and functional maintenance of the placenta, requires precise regulation of immune cells and inflammatory factors at the maternal-fetal interface to establish immune tolerance ( Immunohistochemical analysis of endometrial tissues from PCOS patients revealed an increase in the presence of endometrial inflammatory cells, including macrophages, iDCs, mature dendritic cells (mDCs), and CD8 + T cells ( The NLRP3 inflammasome, which plays a crucial role in the processing of pro-IL-1 and pro-IL-18 into their mature forms through caspase-1, has been significantly increased in the endometrium of women with recurrent miscarriage ( In addition to decreased ER, which contributes to adverse pregnancy outcomes, the chronic inflammation may also be associated with an increased long-term risk of endometrial carcinogenesis in PCOS patients
Gynecol Endocrinol 2008, 24: 411
