Lin Y, Zheng Q, Zheng T, Zheng Z, Lin W, Fu Q
Z.UwechueN
In a rat model, our previous research on early NHPN-1010 treatment for blast-induced tinnitusspecifically targeting cochlear synaptopathydemonstrated that (1) blast overpressure caused a permanent loss of cochlear nerve ribbon synapses (RSs), and (2) administration of NHPN-1010 within 3 days of blast trauma, compared to placebo, significantly rescued RSs, as evidenced by ribbon counts in cochlear histological analyses and corresponding functional changes in suprathreshold wave-I amplitudes of the auditory brainstem response (ABR) 34
Moreover, only 54% of patients in those economics have access to oral cysteamine therapy, and there is limited access to cysteamine eye drops, supportive therapies, and standard diagnostic and monitoring tools, all of which are essential for the prevention of disease progression and extended lifespan [159]
Splitting into morning and evening doses helps maintain consistent levels