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The popularity of GLP-1 drugs has surged worldwide, particularly as weight-loss treatments sold under different brand names

Corticosteroids, topical treatments, and immunotherapy are among the treatment options available, but results may vary

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Notably, when JNK and Nrf2 expression is silenced, AS-IVs protective effects on pancreatic oxidative stress in DKA are diminished, though AS-IV still improves glucose and insulin levels in these juvenile mice (Deng, 2020)

Acknowledgements We thank Gustavo Leone (Medical College of Wisconsin) and Alain deBruin (Utrecht University) for sharing liver-specific E2f7/E2f8 knockout mice