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Am J Ophthalmol 208:281288 Pellegriti G, Frasca F, Regalbuto C, Squatrito S, Vigneri R (2013) Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors

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The mitochondrial ultrastructure was damaged under hypoxia conditions, indicating the breakdown of cellular bioenergetics, which affected the metabolism in TCA cycle ( Glucose 6-phosphate from glycolysis enters the PPP to produce ribose 5-phosphate and nicotinamide adenine dinucleotide phosphate, which drive anabolic metabolism and biomass production ( Pyruvate can be converted into lactate, which is significantly elevated in RA ( AA can be released from membrane phospholipids under hypoxia and inflammatory activation

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Newberry, E

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Type 2 diabetes in adults: management, NICE guideline NG28

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