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While bariatric surgery remains the most effective method for significant and sustained weight loss, its application is often limited by factors such as the availability of skilled surgeons, high costs, and the potential for postoperative complications 9

This framing explicitly links stroke pathophysiology to the buffer concept and clarifies why benefits may be greatest in penumbral and reperfusion contexts rather than the infarct core

Epidemiological studies estimate that the global prevalence of overt hypothyroidism is approximately 4.6% in the United States and 5% in Europe, with even higher rates observed in iodine-deficient regions (Persani, 2012)

Deficiency is associated with increased anxiety and low mood