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Besides eryptotic PS exposure- or immune-mediated clearance, there are also lysis-dependent clearance mechanisms

Mitochondrial respiratory chain complexes I (NADH-CoQ reductase complex), II (succinate dehydrogenase complex), III (cytochrome bc-1 complex) can, under different metabolic stress, produce ROS that damage the mitochondrial membrane, resulting in lipid peroxidation and ultimately leading to ferroptosis

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Trx, thioredoxin

In addition, ML226 inhibition increased Lp glu on the PDHc-E2 (Supplementary Fig