I am grateful to the teams and partners who are driving this work forward
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Key ways it appears to mimic or amplify natural gastrointestinal and tissue repair mechanisms observed in animal studies: Strongly upregulates angiogenesis through multiple pathways (VEGF, EGR-1, FAK-paxillin) in injured tissues, similar to the bodys own response during normal wound healing and tendon/ligament repair
This is evidenced by the fact that we have now identified two different classes of drug, lobeline (monoamine metabolism) and raloxifene (SERM) that clearly function through different mechanisms yet yield the same result: delayed SG disassembly, prolonged ISR activation and increased GBM cell death
doi: 10.1111/dom.12963 [DOI] [PMC free article] [PubMed] [Google Scholar] 172.Gamble JM, Chibrikov E, Midodzi WK, et al