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For patients with end-stage HF, heart transplantation is a worthwhile treatment option

Instead of targeting individual mediators the way antihistamines do, they may help reduce mast cell activation more upstream, potentially dampening the downstream inflammatory cascade

It boosts the fat-burning process by increasing metabolism and transferring fatty acids into the mitochondria

The article lists an eGFR below 60 mL/min/1.73m2 among the situations where creatine should be avoided during GLP-1 therapy, alongside pre-existing kidney disease, uncontrolled hypertension and dehydration

Quotations from the participants are presented using best exemplars to illustrate the themes