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For research models where measurable visceral fat change is the primary endpoint, tesamorelin is the clear choice

DCE-MRI improves the quantification of perfusion and fluid flow due to an increased sensitivity and ability to evaluate changes invisible to conventional MRI methods 178,179,180

Weight Loss of Lizzo is Unknown The amount of weight loss Lizzo has had is not fully known

To match this call for inclusivity, trial design must also evolve, adopting adaptive and master protocols that reflect the complexity of neurodegeneration in the real world