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The existing evidence base consists primarily of mechanistic insights from obesity and diabetes trials, case reports, and extrapolation from studies of other GLP-1 receptor agonists in eating disorders

Outcomes depend on numerous individual factors including baseline hormone levels, pituitary function, adherence, lifestyle factors, and clinician-determined protocols

It decreased GPx activity and GSH content, downregulated GCLC/GCLM expression and then amplified the oxidative signal and weakened the cellular protection