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These properties have established it as a valuable reference compound for investigations involving monoamine transporter biology, transporter-ligand binding dynamics, structure-activity relationships, and mechanistic studies of multi-transporter inhibition systems

For this purpose, we generated PF4 C re R OSA mT/mG (WT) and PF4 C re ROSA mT/mG Thbs1 flox ( TSP1 PF4 KO) reporter mice that constitutively express tdTomato in all cell membranes except in Mgks and platelets which express green fluorescence protein (GFP) under the control of PF4-driven Cre recombinase

for FY 2014, 78 FR 50590 and 50591

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developed the protocol