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She explains that menopausal women often show an increase of antioxidant capacity as well as lower glutathione levels along with high levels of oxidative damage. According to Tennant, this rise in antioxidant capacity may be compensatorya protective response as the body ramps up defenses to counteract mounting oxidative stress.Since glutathione levels decrease while oxidative stress increases, its reasonable to consider supplementing with glutathione or NAC, alongside lifestyle interventions like exercise, diet, sleep, stress management, and possibly hormone replacement therapy, Tennant says

How well they respond to treatment depends on the type and depth of pigmentationmilder, more surface-level cases can often be gently lightened at home

reported no significant differences in glutathione status or oxidative stress biomarkers after 4 weeks of oral glutathione supplementation at 500 mg twice daily [50]

The purpose of this review is to analyze what is reported in the literature in this field, focusing on the molecules and/or strategies that are more suitable to be used as GSH boosters in vivo