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Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

However, this stimulant effect is also why phentermine is strictly a short-term solution

However, costs vary based on dosage and subscription plans, and insurance coverage is often limited

10.26599/FSHW.2022.9250049 519 ZhouQ.SunT.WuF.LiF.LiuY.LiW.et al

Microdermabrasion is also relatively safe for most skin types and tones, as it does not use chemicals or heat, reducing the risk of complications like post-inflammatory hyperpigmentation, which can sometimes occur with laser therapy or chemical peels