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Unlike currently approved weight loss medications, retatrutide works as a triple agonist, meaning it targets three different hormone receptors: GIP, GLP-1, and glucagon receptors

In contrast, GLP-1RAs can regulate the aforementioned key metabolic processes to help impaired hearts restore an energy metabolism pattern approaching normality, with the specific regulatory mechanisms to be elaborated in the section on the mechanism of action of GLP-1RAs

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