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Mice All experiments were approved by the animal ethics committee of Ghent University (EC2013-045, EC2014-065, EC2016-023, EC2017-055, EC2017-097, EC2017-098, EC2017-099, EC2019-013, EC2019-078, EC2020-082, EC2020-106), Antwerp University (2019-19), or by ethic committees and local authorities in Dresden (TVA 07/2021 Landesdirektion Sachsen) and conducted according to institutional, national and European animal regulations