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S14a, b): SC- cells ( INS, NKX6.1 ), SC- cells ( GCG , ARX ), SC- cells ( SST ), SC-pancreatic progenitor cells ( SOX9 ), SC- cells ( GHRL ), and SC-enterochromaffin cells ( FEV ) (Supplementary information, Fig

CBS emerges as the pivotal downstream effector of DDX3X in orchestrating lung cancer progression Given the downregulation of CBS, GCLC, and GCLM in DDX3X-deficient lung cancer cells, we then questioned which enzyme primarily mediates the effects of DDX3X inhibition

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These findings, along with the fact that the lung can normally maintain GSH for long periods even with the oxidant burden of CS, lend credence to the theory that disease symptoms could arise when adaptive responses fail or are dysfunctional

& Donaldson, P