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Neuron 17, 11571172

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19,20,22 A third subgroup consisted of head-to-head studies that compared ALC with another active pharmacological agent (n=2)

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As a core metabolic product, lactate may promote the release of inflammatory mediators (e.g., IL-6, TNF-) by activating the TGF- signaling pathway, while enhancing NF-B pathway activity to exacerbate local inflammatory infiltration in lung tissue but this direct activation has not been demonstrated in COPD airway cells