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Pharmacokinetics and safety of PC-SOD, a lecithinized recombinant superoxide dismutase, in healthy Chinese subjects: A phase 1, randomized, placebo-controlled, dose-escalation study

Together, these data suggest that BDHI is a mildly reactive electrophile that can acts as a covalent protein modifier upon interaction within protein binding pockets and its proteomic reactivity and selectivity can be largely modulated by fragments appended to the warhead

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Inhibiting these SCAPs disrupts the survival machinery of SnCs, triggering their selective apoptosis while sparing normal cells in some contexts 26,27 (Fig