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If you normally absorb 20% of your oral dose and then one day absorb 40% (perhaps due to oral pH changes, a small cut under the tongue, or a different holding technique), you effectively received double your usual dose
Because it is sold as a research chemical, the substance in any given vial is not identity- or purity-assured, which further limits how far trial data (using pharmaceutical-grade material) can be applied to real-world samples
The Km values for SAMe were not affected by the methyl-group acceptors, poly(dIdC)-poly(dIdC) and poly(dG-dC)-poly(dGdC) [47]
[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Kim S.J., Winter K., Nian C., Tsuneoka M., Koda Y., McIntosh C.H