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Importantly, homocysteine at expected ovulation predicted a 33% greater risk of sporadic anovulation, while a higher folate:homocysteine ratio at ovulation was protective, suggesting that maintaining adequate availability of one-carbon cofactors may be most consequential in the peri-ovulatory to early luteal transition when ovulatory competence and luteinization are established [46]

2023;133:e166644

Kirschenbaum MA, Pai R, Roh DD, Kamanna VS

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