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These findings support a comparable cardiovascular benefit of tirzepatide and semaglutide in clinical practice and demonstrate how rigorously designed real-world evidence can complement randomized clinical trials

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Ali Sheffeh, MD After reviewing this study, Sandra Narayanan, MD, a board-certified vascular neurologist and neurointerventional surgeon, of the Pacific Neuroscience Institute at Providence Saint Johns Health Center in Santa Monica, CA, who was not involved in this research, told MNT that she was surprised at powerful the positive response was for both agents to reduce the likelihood of achieving the composite endpoint mortality, heart attack, or recurrent ischemic stroke