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The mitochondria have a membrane around them, and to be oxidized, the glucose or fatty acids have to get through the membrane into the mitochondria
doi: 10.1016/0092-8674(94)90234-8 21 ShimomuraIShimanoHKornBSBashmakovYHortonJD
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We propose that this class of inhibitors trap the NADP + -TGR(H) species, preventing NADP + release
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