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Tirzepatide (10mg-30mg), Dual-Action Incretin Co-Agonist Engineered Engagement of GIP and GLP-1 Receptors Introduction Engineered Engagement of GIP and GLP-1 Receptors Tirzepatide is a 39-residue synthetic peptide engineered to simultaneously activate two distinct incretin receptors, the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R), within a single molecular scaffold

1 Introduction Acetaminophen (APAP), also called paracetamol, is one of the most widely used analgesic and antipyretic over-the-counter drugs in the world (Lee, 2008