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Evidence-based guidelines recommend that FDA-approved medications for addiction treatment be offered at all levels of care, including outpatient, residential, inpatient, and withdrawal management

[5] [6] Once administered intramuscularly (usually into the deltoid or gluteal muscle), hydroxocobalamin is rapidly absorbed into the circulation

Enzymes such as FSP1 and MBOAT1/2 have been identified as important contributors to these pathways, suggesting a broader and more complex regulatory network of ferroptosis beyond the conventional System Xc -GSH-GPX4 axis (Figure 1 offers a comprehensive depiction of the critical molecular mechanisms underpinning ferroptosis

Despite promising findings, gaps in the evidence base, including the need for larger, long-term, and rigorously controlled trials, remain significant barriers to clinical translation

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