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Nat Rev Genet 2013;14:88093
Structurally similar to GLP-1 but unaffected by DPP-4, this peptide lingers in the blood for hours rather than minutes
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These drugs induce a mean weight loss of 1.88kg and also lower blood pressure (mean: 2.46mmHg in systolic and 1.46mmHg in diastolic blood pressure).48 The EMPA-REG,49 CANVAS and CANVAS-R trials,50 conducted in patients with DM2 and high cardiovascular risk, showed empagliflozin and canagliflozin to reduce cardiovascular risk (including cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and hospital admission due to heart failure)
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