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The centrilobular content of P450 increased progressively between five and forty-five days of age, with the characteristic sublobular distribution favoring centrilobular hepatocytes first becoming apparent around seven days of age

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Caffeine is an adenosine analog and has been shown to confer neuroprotection against dopaminergic neurodegeneration via modulation of A 2A R pathways and neuroinflammation in PD models [64]