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In mice, both acute and chronic central administration of exendin-4 increases HR and BP with concomitant decrease in excitatory glutamatergic and inhibitory glycinergic neurotransmission to preganglionic parasympathetic cardiac vagal neurons

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Among them, 21 patients in the placebo group and 12 in the L-carnitine group were dropped out because of consent withdrawal (16 patients in the placebo group and eight in the L-carnitine group), loss to follow-up (two patients in the placebo group), discontinuation due to adverse events (two patients in the placebo group and three in the L-carnitine group), and discontinuation at the investigators discretion (one patient from each group)

(Randomized, double-blind.) See primary paper: Walker et al., Nutrients 2019