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Since semaglutide further slows gastric emptying as part of its mechanism of action, patients with pre-existing gastroparesis may experience worsening of symptoms including nausea, vomiting, bloating, and abdominal discomfort

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Key factors include baseline body weight, adherence to reduced-calorie diet and increased physical activity, presence of type 2 diabetes (which typically results in less weight loss), concurrent medications affecting appetite or metabolism, and individual tolerance to gastrointestinal side effects