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doi: 10.1111/prd.12116

In the current MASLD era, methotrexate-induced hepatotoxicity must be understood in the context of host metabolic dysfunction, obesity, diabetes, and alcohol use that amplify oxidative and inflammatory liver injury

10.1007/s00125-016-4100-7 70

More serious but less common risks include pancreatitis (characterized by severe abdominal pain that may radiate to the back), gallbladder disease, and acute kidney injury from volume depletion

It is required for the function of chaperones such as protein disulfide isomerases and calreticulin, which facilitate disulfide bond formation and ensure proper protein conformation 59